Oxidative phosphorylation dysfunction modifies the cell secretome

Garrido-Pérez, Nuria (Universidad de Zaragoza) ; Vela-Sebastián, Ana (Universidad de Zaragoza) ; López-Gallardo, Ester (Universidad de Zaragoza) ; Emperador, Sonia (Universidad de Zaragoza) ; Iglesias, Eldris (Universidad de Zaragoza) ; Meade, Patricia (Universidad de Zaragoza) ; Jiménez-Mallebrera, Cecilia ; Montoya, Julio (Universidad de Zaragoza) ; Bayona-Bafaluy, M. Pilar (Universidad de Zaragoza) ; Ruiz-Pesini, Eduardo (Universidad de Zaragoza)

Resumen: Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell’s secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. We propose two new biomarkers to be taken into account in future diagnostic trials.

Idioma: Inglés

DOI: 10.3390/ijms21093374

Año: 2020

Publicado en: International Journal of Molecular Sciences 21, 9 (2020), 3374 [16 pp.]
ISSN: 1661-6596

Factor impacto JCR: 5.923 (2020)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 67 / 297 = 0.226 (2020) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 49 / 178 = 0.275 (2020) - Q2 - T1

Factor impacto SCIMAGO: 1.455 - Catalysis (Q1) - Computer Science Applications (Q1) - Inorganic Chemistry (Q1) - Spectroscopy (Q1) - Molecular Biology (Q1) - Organic Chemistry (Q1) - Physical and Theoretical Chemistry (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B33-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI19-0122

Tipo y forma: Review (Published version)

Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)