Antibacterial effect of thymol loaded SBA-15 nanorods incorporated in PCL electrospun fibers

Gámez, Enrique ; Elizondo-Castillo, Hellen ; Tascon, Jorge ; García-Salinas, Sara (Universidad de Zaragoza) ; Navascues, Nuria ; Mendoza, Gracia (Universidad de Zaragoza) ; Arruebo, Manuel (Universidad de Zaragoza) ; Irusta, Silvia (Universidad de Zaragoza)

Resumen: For the effective management of infected chronic wounds, the incorporation of antimicrobial drugs into wound dressings can increase their local availability at the infection site. Mesoporous silicon dioxide SBA-15 is an excellent drug carrier with tunable drug release kinetics. In this work, synthesized SBA-15 loaded with the natural antimicrobial compound thymol (THY) was incorporated into polycaprolactone (PCL) electrospun nanofibers to obtain an advanced wound dressing. Rod-shaped particles with internal parallel channels oriented along the longitudinal axis (diameter: 138 ± 30 nm, length: 563 ± 100 nm) were loaded with 70.8 wt.% of THY. Fiber mats were prepared using these particles as nanofillers within polycaprolactone (PCL) electrospun fibers. The resulting mats contained 5.6 wt.% of THY and more than half of this loading was released in the first 7 h. This release would prevent an initial bacterial colonization and also inhibit or eliminate bacterial growth as in vitro shown against Staphylococcus aureus ATCC 25923. Minimal inhibitory concentration (MIC: 0.07 mg/mL) and minimal bactericidal concentration (MBC: 0.11 mg/mL) of released THY were lower than the amount of free THY required, demonstrating the benefit of drug encapsulation for a more efficient bactericidal capacity due to the direct contact between mats and bacteria.

Idioma: Inglés

DOI: 10.3390/nano10040616

Año: 2020

Publicado en: Nanomaterials 10, 4 (2020), 616 [13 pp.]
ISSN: 2079-4991

Factor impacto JCR: 5.076 (2020)

Categ. JCR: PHYSICS, APPLIED rank: 35 / 160 = 0.219 (2020) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 51 / 106 = 0.481 (2020) - Q2 - T2
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 55 / 178 = 0.309 (2020) - Q2 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 103 / 333 = 0.309 (2020) - Q2 - T1

Factor impacto SCIMAGO: 0.919 - Materials Science (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-52384-R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Tecnologi. Medio Ambiente (Dpto. Ing.Quím.Tecnol.Med.Amb.)