Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery
Sánchez-Ortega, J.F. ; Aguas-Valiente, J. (Universidad de Zaragoza) ; Sota-Ochoa, P. (Universidad de Zaragoza) ; Calatayud-Pérez, J. (Universidad de Zaragoza)
Resumen: Background: Glioblastoma with primitive neuronal components (GB/PNC) is an extremely rare type of glioblastoma characterized by presenting histological and cytogenetic features of both entities. The mixed nature of these tumors limits the imaging diagnosis and supposes a therapeutic dilemma.
Case Description: We present the case of a 77-year-old female with a GB/PNC who is treated with surgery and adjuvant radiochemotherapy according to the STUPP protocol, where an abnormal uptake of 5-aminolevulinic acid (5-ALA) is evident during surgery in probable relation to the mixed nature of GB/PNC.
Conclusion: GB/PNC is extremely rare tumors. Given its low prevalence, there are no studies that refer to the macroscopic characteristics of the tumor as well as evidence of the effectiveness of adjuvant treatment. Fluorescence-guided resection with 5-ALA is the surgical treatment of choice in surgery for high-grade gliomas; however, in GB/PNC, it may not be as useful since PNC may have less fluorescent marker uptake and be more dimly visualized when excited by light using the surgical microscope.
Idioma: Inglés
DOI: 10.25259/SNI_272_2020
Año: 2020
Publicado en: Surgical Neurology International 11, 178 (2020), [5 pp]
ISSN: 2152-7806
Factor impacto SCIMAGO: 0.433 - Surgery (Q3) - Neurology (clinical) (Q3)
Tipo y forma: Article (Published version)
Área (Departamento): Área Cirugía (Dpto. Cirugía)
Área (Departamento): Área Anatomía Patológica (Dpto. Cirugía)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
Exportado de SIDERAL (2023-09-13-10:51:11)
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Case Description: We present the case of a 77-year-old female with a GB/PNC who is treated with surgery and adjuvant radiochemotherapy according to the STUPP protocol, where an abnormal uptake of 5-aminolevulinic acid (5-ALA) is evident during surgery in probable relation to the mixed nature of GB/PNC.
Conclusion: GB/PNC is extremely rare tumors. Given its low prevalence, there are no studies that refer to the macroscopic characteristics of the tumor as well as evidence of the effectiveness of adjuvant treatment. Fluorescence-guided resection with 5-ALA is the surgical treatment of choice in surgery for high-grade gliomas; however, in GB/PNC, it may not be as useful since PNC may have less fluorescent marker uptake and be more dimly visualized when excited by light using the surgical microscope.
Idioma: Inglés
DOI: 10.25259/SNI_272_2020
Año: 2020
Publicado en: Surgical Neurology International 11, 178 (2020), [5 pp]
ISSN: 2152-7806
Factor impacto SCIMAGO: 0.433 - Surgery (Q3) - Neurology (clinical) (Q3)
Tipo y forma: Article (Published version)
Área (Departamento): Área Cirugía (Dpto. Cirugía)
Área (Departamento): Área Anatomía Patológica (Dpto. Cirugía)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. Exportado de SIDERAL (2023-09-13-10:51:11)
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Record created 2020-10-09, last modified 2023-09-14