X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline

Anguita-Ruiz, Augusto ; Plaza-Diaz, Julio ; Ruiz-Ojeda, Francisco Javier ; Ruperez, Azahara I. (Universidad de Zaragoza) ; Leis, Rosaura ; Bueno, Gloria (Universidad de Zaragoza) ; Gil-Campos, Mercedes ; Vazquez-Cobela, Rocío ; Canete, Ramón ; Moreno, Luis A. (Universidad de Zaragoza) ; Gil, Ángel ; Aguilera, Concepción María

Resumen: X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics have been developed, there is also a lack of readily available implementations for routine analysis. Here, we aimed: (1) to make public and describe a dataset incorporating phenotype and X chromosome genotype data from a cohort of 915 normal-weight, overweight and obese children, and (2) to deeply describe a whole implementation of the special X chromosome analytic process in genetics. Datasets and pipelines like this are crucial to get familiar with the steps in which X chromosome requires special attention and may raise awareness of the importance of this genomic region.

Idioma: Inglés

DOI: 10.1038/s41597-019-0109-3

Año: 2019

Publicado en: SCIENTIFIC DATA 6 (2019), 130 [10 pp]
ISSN: 2052-4463

Factor impacto JCR: 5.541 (2019)

Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 11 / 71 = 0.155 (2019) - Q1 - T1

Factor impacto SCIMAGO: 3.099 - Computer Science Applications (Q1) - Education (Q1) - Statistics, Probability and Uncertainty (Q1) - Library and Information Sciences (Q1) - Statistics and Probability (Q1) - Information Systems (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI051968
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI1102042
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI1600871
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/i-PFIS-IFI17-00048
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0026-0015

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Pediatría (Dpto. Pediatría Radiol.Med.Fís)