Methylene blue? Therapeutic alternative in the management of septic shock refractory to norepinephrine

Aragón-Benedí, C. ; Pascual-Bellosta, A. (Universidad de Zaragoza) ; Ortega-Lucea, S. (Universidad de Zaragoza) ; Lacosta-Torrijos, L. ; Jiménez-Bernadó, T. (Universidad de Zaragoza) ; Martínez-Ubieto, J. (Universidad de Zaragoza)

Resumen: Introduction: Methylene blue is receiving special interest in perioperative and intensive care of patients with distributive shock due to its ability to block the action of nitric oxide and to antagonize deep vasodilation.
Objective: The objective is to illustrate the use of the methylene blue, summarizing the perioperative management of a case with secondary vasoplegic syndrome due to a norepinephrine refractory septic shock and the response to methylene blue, reviewing the latest evidence of this therapeutic alternative. In practice:We describe the case of a 60-year-old man, paraplegic, with septic shock due to a long evolution decubitus pressure ulcer. After two hours of surgery, the patient remained with hemodynamic deterioration despite high doses of vasopressin (3 IU/hour) and norepinephrine (2 µg/kg /min), therefore methylene blue was administered with two intravenous bolus doses of 50 mg without adverse effects. After half an hour hemodynamic improvement was evidenced, allowing to decrease norepinephrine infusion and normalizing blood pressure. Finally, debridement of necrotic tissue, amputation and disarticulation of left coxofemoral joint was performed with subsequent transfer to the ICU and discharge to the spinal cord injury ward twenty eight days later.
Conclusions: As it has been demonstrated in our patient, methylene blue is a therapeutic alternative to manage patients with persistent hypotension despite the use of various vasopressors during the management of vasoplegic syndrome secondary to septic shock.

Idioma: Inglés

DOI: 10.22514/sv.2020.16.0063

Año: 2020

Publicado en: Signa Vitae 16, 2 (2020), 199-202
ISSN: 1334-5605

Factor impacto JCR: 0.63 (2020)

Categ. JCR: EMERGENCY MEDICINE rank: 30 / 32 = 0.938 (2020) - Q4 - T3

Factor impacto SCIMAGO: 0.14 - Emergency Medicine (Q4) - Critical Care and Intensive Care Medicine (Q4)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B26-17D

Tipo y forma: Article (Published version)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Cirugía (Dpto. Cirugía)