The ''Digital Twin'' to enable the vision of precision cardiology

Corral-Acero, J. ; Margara, F. ; Marciniak, M. ; Rodero, C. ; Loncaric, F. ; Feng, Y. ; Gilbert, A. ; Fernandes, J.F. ; Bukhari, H.A. (Universidad de Zaragoza) ; Wajdan, A. ; Martinez, M.V. ; Santos, M.S. ; Shamohammdi, M. ; Luo, H. ; Westphal, P. ; Leeson, P. ; DiAchille, P. ; Gurev, V. ; Mayr, M. ; Geris, L. ; Pathmanathan, P. ; Morrison, T. ; Cornelussen, R. ; Prinzen, F. ; Delhaas, T. ; Doltra, A. ; Sitges, M. ; Vigmond, E.J. ; Zacur, E. ; Grau, V. ; Rodriguez, B. ; Remme, E.W. ; Niederer, S. ; Mortier, P. ; McLeod, K. ; Potse, M. ; Pueyo, E. (Universidad de Zaragoza) ; Bueno-Orovio, A. ; Lamata, P.

Resumen: Providing therapies tailored to each patient is the vision of precision medicine, enabled by the increasing ability to capture extensive data about individual patients. In this position paper, we argue that the second enabling pillar towards this vision is the increasing power of computers and algorithms to learn, reason, and build the ''digital twin'' of a patient. Computational models are boosting the capacity to draw diagnosis and prognosis, and future treatments will be tailored not only to current health status and data, but also to an accurate projection of the pathways to restore health by model predictions. The early steps of the digital twin in the area of cardiovascular medicine are reviewed in this article, together with a discussion of the challenges and opportunities ahead. We emphasize the synergies between mechanistic and statistical models in accelerating cardiovascular research and enabling the vision of precision medicine.

Idioma: Inglés

DOI: 10.1093/eurheartj/ehaa159

Año: 2020

Publicado en: European heart journal 41, 48 (2020), 4556-4564
ISSN: 0195-668X

Factor impacto JCR: 29.983 (2020)

Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 2 / 141 = 0.014 (2020) - Q1 - T1

Factor impacto SCIMAGO: 4.336 - Cardiology and Cardiovascular Medicine (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/675451/EU/A Centre of Excellence in Computational Biomedicine/CompBioMed
Financiación: info:eu-repo/grantAgreement/EC/H2020/764738/EU/Personalised In-Silico Cardiology/PIC
Financiación: info:eu-repo/grantAgreement/EC/H2020/766082/EU/MultidisciplinarY training network for ATrial fibRillation monItoring, treAtment and progression/MY-ATRIA
Financiación: info:eu-repo/grantAgreement/EC/H2020/823712/EU/A Centre of Excellence in Computational Biomedicine/CompBioMed2

Tipo y forma: Article (Published version)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)