A novel score for predicting alzheimer’s disease risk from late life psychopathological and health risk factors

Santabárbara, J. (Universidad de Zaragoza) ; Bueno-Notivol, J. ; Lipnicki, D.M. ; de la Cámara, C. (Universidad de Zaragoza) ; López-Antón, R. (Universidad de Zaragoza) ; Lobo, A. (Universidad de Zaragoza) ; Gracia-García, P. (Universidad de Zaragoza)

Resumen: With the increasing size of the aging population, dementia risk reduction has become a main public health concern. Dementia risk models or indices may help to identify individuals in the community at high risk to develop dementia. We have aimed to develop a novel dementia risk index focused on the late-life (65 years or more) population, that addresses risk factors for Alz-heimer’s disease (AD) easily identifiable at primary care settings. These risk factors include some shown to be associated with the risk of AD but not featured in existing indices, such as hearing loss and anxiety. Our index is also the first to account for the competing risk of death. The Zaragoza Dementia and Depression Project (ZARADEMP) Alzheimer Dementia Risk Score predicts an indi-vidual´s risk of developing AD within 5 years. The probability of late onset AD significantly in-creases in those with risk scores between 21 and 28 and, furthermore, is almost 4-fold higher for those with risk scores of 29 or higher. Our index may provide a practical instrument to identify subjects at high risk of AD and to design preventive strategies targeting the contributing risk factors.

Idioma: Inglés

DOI: 10.3390/ijerph18041802

Año: 2021

Publicado en: International journal of environmental research and public health 18, 4 (2021), 1802 [14 pp]
ISSN: 1661-7827

Factor impacto JCR: 4.614 (2021)

Categ. JCR: PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH rank: 45 / 183 = 0.246 (2021) - Q1 - T1
Categ. JCR: PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH rank: 71 / 210 = 0.338 (2021) - Q2 - T2
Categ. JCR: ENVIRONMENTAL SCIENCES rank: 100 / 279 = 0.358 (2021) - Q2 - T2

Factor impacto CITESCORE: 4.5 - Medicine (Q2) - Environmental Science (Q2)

Factor impacto SCIMAGO: 0.814 - Pollution (Q1) - Health, Toxicology and Mutagenesis (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B15-17R
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/PI16-00896
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Una manera de hacer Europa
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128R
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI-19-01874
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103

Tipo y forma: Article (Published version)

Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)