Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

Vierboom, M.P.M. ; Dijkman, K. ; Sombroek, C.C. ; Hofman, S.O. ; Boot, C. ; Vervenne, R.A.W. ; Haanstra, K.G. ; van der Sande, M. ; van Emst, L. ; Domínguez-Andrés, J. ; Moorlag, S.J.C.F.M. ; Kocken, C.H.M. ; Thole, J. ; Rodríguez, E. ; Puentes, E. ; Martens, J.H.A. ; van Crevel, R. ; Netea, M.G. ; Aguilo, N. (Universidad de Zaragoza) ; Martin, C. (Universidad de Zaragoza) ; Verreck, F.A.W.

Resumen: Vierboom et al. demonstrate the induction of trained immunity in blood and bone marrow monocytes after vaccination with live attenuated TB vaccines in nonhuman primates. Mucosal respiratory delivery of BCG or MTBVAC induces trained immunity more efficiently compared to standard intradermal vaccination.

Idioma: Inglés

DOI: 10.1016/j.xcrm.2020.100185

Año: 2021

Publicado en: Cell reports medicine 2, 1 (2021), 100185 [20 pp]
ISSN: 2666-3791

Factor impacto JCR: 16.988 (2021)

Categ. JCR: MEDICINE, RESEARCH & EXPERIMENTAL rank: 5 / 140 = 0.036 (2021) - Q1 - T1
Categ. JCR: CELL BIOLOGY rank: 17 / 195 = 0.087 (2021) - Q1 - T1

Factor impacto CITESCORE: 7.1 - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 5.956 - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/643381/EU/TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development/TBVAC2020
Financiación: info:eu-repo/grantAgreement/EC/H2020/730964/EU/European Vaccine Research and Development Infrastructure/TRANSVAC2

Tipo y forma: Article (Published version)

Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)