Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain

Cañada, J.E. ; Delgado, E. ; Gil, H. ; Sánchez, M. ; Benito, S. ; García-Bodas, E. ; Gómez-González, C. ; Canut-Blasco, A. ; Portu-Zapirain, J. ; Sáez de Adana, E. ; De la Peña, M. ; Ibarra, S. ; Cilla, G. ; Iribarren, J.A. ; Martínez-Sapiña, A. ; Thomson, M.M.

Resumen: The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms. Among CRFs, 11 derived from subtypes B and C have been identified in China, Brazil, and Italy. Here we identify a new HIV-1 CRF_BC in Northern Spain. Originally, a phylogenetic cluster of 15 viruses of subtype C in protease-reverse transcriptase was identified in an HIV-1 molecular surveillance study in Spain, most of them from individuals from the Basque Country and heterosexually transmitted. Analyses of near full-length genome sequences from six viruses from three cities revealed that they were BC recombinant with coincident mosaic structures different from known CRFs. This allowed the definition of a new HIV-1 CRF designated CRF108_BC, whose genome is predominantly of subtype C, with four short subtype B fragments. Phylogenetic analyses with database sequences supported a Brazilian ancestry of the parental subtype C strain. Coalescent Bayesian analyses estimated the most recent common ancestor of CRF108_BC in the city of Vitoria, Basque Country, around 2000. CRF108_BC is the first CRF_BC identified in Spain and the second in Europe, after CRF60_BC, both phylogenetically related to Brazilian subtype C strains.

Idioma: Inglés

DOI: 10.3390/v13010093

Año: 2021

Publicado en: VIRUSES-BASEL 13, 1 (2021), 93 [13 pp]
ISSN: 1999-4915

Factor impacto JCR: 5.818 (2021)

Categ. JCR: VIROLOGY rank: 14 / 37 = 0.378 (2021) - Q2 - T2

Factor impacto CITESCORE: 6.6 - Medicine (Q1) - Immunology and Microbiology (Q2)

Factor impacto SCIMAGO: 1.463 - Virology (Q1) - Infectious Diseases (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-AESI/PI16CIII-00033
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-AESI/PI19CIII-00042
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-RIS-FEDER/RD16ISCIII-0002-0004

Tipo y forma: Article (Published version)