Multiscale modeling of bone tissue Mechanobiology

García-Aznar, José Manuel (Universidad de Zaragoza) ; Nasello, Gabriele ; Hervas-Raluy, Silvia (Universidad de Zaragoza) ; Pérez Ansón, María de los Ángeles (Universidad de Zaragoza) ; Gómez-Benito, María José (Universidad de Zaragoza)

Resumen: Mechanical environment has a crucial role in our organism at the different levels, ranging from cells to tissues and our own organs. This regulatory role is especially relevant for bones, given their importance as load-transmitting elements that allow the movement of our body as well as the protection of vital organs from load impacts. Therefore bone, as living tissue, is continuously adapting its properties, shape and repairing itself, being the mechanical loads one of the main regulatory stimuli that modulate this adaptive behavior. Here we review some key results of bone mechanobiology from computational models, describing the effect that changes associated to the mechanical environment induce in bone response, implant design and scaffold-driven bone regeneration.

Idioma: Inglés

DOI: 10.1016/j.bone.2021.116032

Año: 2021

Publicado en: BONE 151, 116032 (2021), [12 pp.]
ISSN: 8756-3282

Factor impacto JCR: 4.626 (2021)

Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 60 / 147 = 0.408 (2021) - Q2 - T2

Factor impacto CITESCORE: 7.4 - Medicine (Q1) - Biochemistry, Genetics and Molecular Biology (Q1)

Factor impacto SCIMAGO: 1.086 - Histology (Q1) - Endocrinology, Diabetes and Metabolism (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/722535/EU/Predictive models and simulations in bone regeneration: a multiscale patient-specific approach/CuraBone
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C21
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84780-C2-1-R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)