A numerical investigation of changes in lens shape during accommodation

Cabeza-Gil, I. (Universidad de Zaragoza) ; Grasa, J. (Universidad de Zaragoza) ; Calvo, B. (Universidad de Zaragoza)
A numerical investigation of changes in lens shape during accommodation
Resumen: The purpose of this study was to investigate how the mechanical properties and geometry of the lens influence the changes in lens shape during accommodation. To do so, ex vivo stretching tests of the isolated lens were simulated via finite element analysis. In these tests, the lens is stretched from the accommodated state to the non-accommodated state. Several key characteristics of the lens were studied: the stiffness gradient of the lens material, the distribution of the capsule thickness, the mechanical properties of the capsule and the material comprising the lens, nucleus and cortex, and the influence of two different age-related lens geometries (17 and 29 y/o subjects). To determine the effects on the changes in lens shape during accommodation, changes in the anterior and posterior radius, the lens and nucleus thicknesses and the equatorial lens diameter were analysed. The results suggest that multiple factors exert statistically significant influences on how the lens changes its shape, but two factors predominate over the rest: the stiffness ratio between the nucleus and cortex and the stiffness of the capsule, specifically the posterior surface.
Idioma: Inglés
DOI: 10.1038/s41598-021-89145-z
Año: 2021
Publicado en: Scientific reports (Nature Publishing Group) 11 (2021), 9639 [12 pp.]
ISSN: 2045-2322

Factor impacto JCR: 4.997 (2021)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 19 / 74 = 0.257 (2021) - Q2 - T1
Factor impacto SCIMAGO: 1.005 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84047-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PRE2018-084021
Financiación: info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U27 Unit-CIBER-BBN
Tipo y forma: Article (Published version)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)

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 Record created 2021-12-16, last modified 2023-12-15

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