Nitrogen-doped carbon nanodots deposited on titania nanoparticles: unconventional near-infrared active photocatalysts for cancer therapy

Madrid, A. ; Martín-Pardillos, A. (Universidad de Zaragoza) ; Bonet-Aleta, J. (Universidad de Zaragoza) ; Sancho-Albero, M. (Universidad de Zaragoza) ; Martinez, G. (Universidad de Zaragoza) ; Calzada-Funes, J. ; Martin-Duque, P. (Universidad de Zaragoza) ; Santamaria, J. (Universidad de Zaragoza) ; Hueso, J. L. (Universidad de Zaragoza)

Resumen: Cancer represents a major public health issue and a primary cause of death for the mankind and the search for alternative cancer treatments that assist or alleviate the drawbacks of current cancer therapies remains imperative. Nanocatalytic medicine represents a new discipline that aims at exploiting the unique response of heterogeneous catalysts exposed to unconventional conditions such as those encountered in the tumor microenvironment (TME). Photo-triggered cancer therapies using light-activable catalytic materiales can stimulate and activate multiple biological processes and represent a very promising field of study. Herein, we evaluate the use of carbon nanodots with different composition (CNDs) retrieved by laser pyrolysis as potential near-infrared (NIR) photosensitizers able to activate P25 semiconductor nanostructured photocatalysts. We describe the enhanced photocatalytic response towards glucose conversion and reactive oxygen species (ROS) generation upon irradiation with NIR-LEDs when CNDs doped with heteroatoms were tested. The most active photocatalysts were evaluated in the presence of cancer cells and revealed a promising photodynamic effect under NIR irradiation. This work represents one of the scarce examples of a conventional inorganic photocatalyst containing TiO2 that is translated into a biomedical application with a successful outcome.

Idioma: Inglés

DOI: 10.1016/j.cattod.2023.114154

Año: 2023

Publicado en: Catalysis Today 419 (2023), 114154 [8 pp.]
ISSN: 0920-5861

Factor impacto JCR: 5.2 (2023)

Categ. JCR: CHEMISTRY, APPLIED rank: 13 / 74 = 0.176 (2023) - Q1 - T1
Categ. JCR: ENGINEERING, CHEMICAL rank: 35 / 170 = 0.206 (2023) - Q1 - T1
Categ. JCR: CHEMISTRY, PHYSICAL rank: 60 / 178 = 0.337 (2023) - Q2 - T2

Factor impacto CITESCORE: 11.5 - Chemistry (all) (Q1) - Catalysis (Q1)

Factor impacto SCIMAGO: 1.022 - Chemistry (miscellaneous) (Q1) - Catalysis (Q2)

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2020-114926RB-I00
Financiación: info:eu-repo/grantAgreement/EC/FP7/294094/EU/Synthesis and characterization of NANOstructured materials with LumInescent properties for diaGnostic and tHerapeuTic applications/NANOLIGHT
Financiación: info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE
Financiación: info:eu-repo/grantAgreement/ES/ISCIII DTS21-00130
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI19-01007

Tipo y forma: Article (Published version)

Área (Departamento): Área Estomatología (Dpto. Cirugía)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)