Serum plant sterols as surrogate markers of dietary compliance infamilial dyslipidemias

Mateo-Gallego, R. ; Baila-Rueda, L. ; Mouratidou, T. ; De Castro-Orós, I. ; Bea, A. M. ; Pérez-Calahorra, S. (Universidad de Zaragoza) ; Cenarro, A. ; Moreno, L. A. (Universidad de Zaragoza) ; Civeira, F. (Universidad de Zaragoza)

Resumen: Background & aims: A well-balanced diet is the first-line treatment in hyperlipidemia. The objective was to study the association between serum phytosterols and dietary patterns to use them as surrogate markers of dietary compliance in primary dyslipidemias. Methods: 288 patients with primary hyperlipidemias (192 autosomal dominant hypercholesterolemia (ADH) and 96 familial combined hyperlipidemia (FCHL)) were included. Principal factor analysis identified 2 major dietary patterns using a 137-item food frequency questionnaire. “Vegetable & Fruits pattern” was characterized by higher intake of fruits, green beans, nuts, tomatoes, roasted or boiled potatoes, lettuce and chard and lower of processed baked goods, pizza and beer. “Western pattern” was positively characterized by hamburgers, pasta, sunflower oil, rice, chickpeas, whole milk, veal, red beans and negatively with white fish. Serum non-cholesterol sterols were determined by HPLC-MS/MS. Results: Plant sterols to-total cholesterol (TC) levels were lower with a higher adherence to a “Vegetable & Fruits pattern” (P = 0.009), mainly in ADH subjects (R2 = 0.019). Their concentration was greater with higher compliance to “Western pattern” especially in FCHL (P = 0.014). Higher levels of synthesis markers-to-TC with a greater adherence to “Vegetable & Fruits pattern” were found (P = 0.001) (R2 = 0.033 and R2 = 0.109 in ADH and FCHL respectively). Conclusion: In subjects with primary dislipidemia, dietary patterns associate with serum absorption and synthesis markers, but no with lipid concentrations. The influence of diet on non-cholesterol sterols levels is not powerful enough to use them as subrogate markers.

Idioma: Inglés

DOI: 10.1016/j.clnu.2014.05.011

Año: 2015

Publicado en: Clinical Nutrition 34, 3 (2015), 490-495
ISSN: 0261-5614

Factor impacto JCR: 4.487 (2015)

Categ. JCR: NUTRITION & DIETETICS rank: 10 / 80 = 0.125 (2015) - Q1 - T1

Factor impacto SCIMAGO: 1.79 - Nutrition and Dietetics (Q1) - Critical Care and Intensive Care Medicine (Q1)

Financiación: info:eu-repo/grantAgreement/ES/FIS/PI12-01087
Financiación: info:eu-repo/grantAgreement/ES/FIS/RETIC-RD12-0042-0055

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)