Decrease of oxidative phosphorylation system function in severe septic patients

Lorente, L. ; Martín, M. M. ; López-Gallardo, E. (Universidad de Zaragoza) ; Blanquer, J. ; Solé-Violán, J. ; Labarta, L. ; Díaz, C. ; Jiménez, A. (Universidad de Zaragoza) ; Montoya, J. ; Ruiz-Pesini, E. (Universidad de Zaragoza)

Resumen: Objective
The comparison of oxidative phosphorylation system capacities between septic patients and control subjects has been scarcely analyzed and only in studies with small sample size (fewer than 40 septic patients and 40 controls). Thus, the objective of this study was to compare platelet respiratory complex IV (CIV) activity between severe septic patients and healthy individuals in a larger series (including 198 severe septic patients and 96 healthy controls).

Methods
A prospective, multicenter, observational study was carried out in 6 Spanish intensive care units. We obtained blood samples from 198 severe septic patients at day 1, 4, and 8 of the severe sepsis diagnosis and 96 sex- and age-matched healthy control individuals and determined platelet CIV-specific activity. The end point of the study was 30-day mortality.

Results
Control individuals showed higher platelet CIV-specific activity (P < .001) than surviving (n = 130) or nonsurviving (n = 68) severe septic patients at day 1, 4, and 8 of severe sepsis diagnosis.

Conclusions
The major finding of our work, involving the largest series to date of severe septic patients with data on oxidative phosphorylation system capacity, was that surviving and nonsurviving septic patients showed lower platelet CIV-specific activity during the first week of sepsis than healthy controls.

Idioma: Inglés

DOI: 10.1016/j.jcrc.2015.05.031

Año: 2015

Publicado en: JOURNAL OF CRITICAL CARE 30, 5 (2015), 935-939
ISSN: 0883-9441

Factor impacto JCR: 2.445 (2015)

Categ. JCR: CRITICAL CARE MEDICINE rank: 18 / 33 = 0.545 (2015) - Q3 - T2

Factor impacto SCIMAGO: 1.186 - Critical Care and Intensive Care Medicine (Q1)

Tipo y forma: Article (Published version)

Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)