Maternally inherited susceptibility to cancer

Bayona-Bafaluy, M. (Universidad de Zaragoza) ; López-Gallardo, E. (Universidad de Zaragoza) ; Montoya, J. (Universidad de Zaragoza) ; Ruiz-Pesini, E. (Universidad de Zaragoza)

Resumen: Tumor microenvironment promotes mtDNA mutations. A number of these mutations will affect cell metabolism and increase cell survival. These mutations are positively selected and contribute to other tumor features, such as extracellular matrix remodeling and angiogenic processes, thus favoring metastases. Like somatic mutations, although with less marked effects, some mtDNA population polymorphisms will affect OXPHOS function, cell metabolism, and homeostasis. Thus, they could behave as inherited susceptibility factors for cancer. However, in addition to epidemiological evidence, other more direct clues are required. The cybrid approach can help to clarify this issue. This article is part of a Special Issue entitled: Bioenergetics of Cancer.

Idioma: Inglés

DOI: 10.1016/j.bbabio.2010.08.004

Año: 2011

Publicado en: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1807, 6 (2011), 643-649
ISSN: 0005-2728

Factor impacto JCR: 4.843 (2011)

Categ. JCR: BIOPHYSICS rank: 13 / 71 = 0.183 (2011) - Q1 - T1
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 63 / 287 = 0.22 (2011) - Q1 - T1

Tipo y forma: Article (Published version)

Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)