Nanosilver-based materials as feed additives: Evaluation of their transformations along in vitro gastrointestinal digestion in pigs and chickens by using an ICP-MS based analytical platform

Ben-Jeddou, Khaoula ; Bakir, Mariam ; Jiménez, María S. (Universidad de Zaragoza) ; Gómez, María T. (Universidad de Zaragoza) ; Abad-Álvaro, Isabel (Universidad de Zaragoza) ; Laborda, Francisco (Universidad de Zaragoza)

Resumen: The use of a new nanomaterial in the feed chain requires a risk assessment that involves in vitro gastrointestinal digestions to predict its degradation and oral exposure to nanoparticles. In this study, a nanosilver-based material was incorporated into pig and chicken feed as a growth-promoting additive and subjected to the corresponding in vitro gastrointestinal digestions. An inductively coupled plasma mass spectroscopy (ICP-MS) analytical platform was used to obtain information about the silver released in the different digestion phases. It included conventional ICP-MS for total silver determination, but also single particle ICP-MS and coupling to hydrodynamic chromatography for detection of dissolved and particulate silver. The bioaccessible fraction in the intestinal phase accounted for 8–13% of the total silver, mainly in the form of dissolved Ag(I) species, with less than 0.1% as silver-containing particles. Despite the additive behaving differently in pig and chicken digestions, the feed matrix played a relevant role in the fate of the silver.

Idioma: Inglés

DOI: 10.1007/s00216-024-05323-8

Año: 2024

Publicado en: Analytical and Bioanalytical Chemistry 416 (2024), 3821-3833
ISSN: 1618-2642

Factor impacto JCR: 3.8 (2024)

Categ. JCR: BIOCHEMICAL RESEARCH METHODS rank: 21 / 86 = 0.244 (2024) - Q1 - T1
Categ. JCR: CHEMISTRY, ANALYTICAL rank: 31 / 111 = 0.279 (2024) - Q2 - T1

Factor impacto SCIMAGO: 0.716 - Biochemistry (Q2) - Analytical Chemistry (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/E29-23R
Financiación: info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2021-123203OB-I00
Financiación: info:eu-repo/grantAgreement/ES/NextGenerationEU/MZ-240621

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Analítica (Dpto. Química Analítica)