Neuroprotective effects of whey and buttermilk-based formulas on a DSS-induced colitis murine model

Buey, Berta ; Latorre, Eva (Universidad de Zaragoza) ; Castro, Marta (Universidad de Zaragoza) ; Valero, Marta Sofía (Universidad de Zaragoza) ; Plaza, Miguel Ángel (Universidad de Zaragoza) ; Arruebo, María Pilar (Universidad de Zaragoza) ; Abad, Inés ; Rodríguez-Largo, Ana ; Sánchez, Lourdes (Universidad de Zaragoza) ; Mesonero, José Emilio (Universidad de Zaragoza)

Resumen: Inflammatory bowel disease is a gut–brain axis disorder that comprises chronic inflammatory conditions affecting the gastrointestinal tract, where alterations in the mood of patients are common. Gut–brain axis is a bidirectional communication that link gut and brain. The close association between inflammatory bowel disease and neuroinflammation has far-reaching implications, as is increasingly recognized as a contributing factor to neuropsychiatric and neurodegenerative diseases. The increasing prevalence and high economic cost, together with the loss of life quality of people suffering from these diseases, point to the need to find alternatives to alleviate them. Exploring new therapeutic avenues prompts us to consider the potential benefits of milk fractions, taking advantage of the use of dairy by-products, such as whey and buttermilk. This study examines the impact of cow’s whey- and buttermilk-based formulas supplemented with bovine lactoferrin and milk fat globule membrane on the expression of cytokines, as well as on the components of immune and serotonergic system of the brain in a murine model of dextran sodium sulfate-induced colitis. Our results show the potential of these dairy by-products, especially whey, as functional foods in ameliorating neuroinflammation and safeguarding the central nervous system function amid the neurological complications induced or concomitant with intestinal inflammatory processes.

Idioma: Inglés

DOI: 10.1139/bcb-2024-0153

Año: 2025

Publicado en: BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 103 (2025), 1-11
ISSN: 0829-8211

Financiación: info:eu-repo/grantAgreement/ES/DGA/A20-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA/A20-23R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2017-82987

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)
Área (Departamento): Área Tecnología de Alimentos (Dpto. Produc.Animal Cienc.Ali.)