Listeria monocytogenes affects serotonin transporter activity and expression in human intestinal epithelial cells by TLR10 activation

Latorre, E. ; Pradilla, A. ; Chueca, B. (Universidad de Zaragoza) ; Pagan, R. (Universidad de Zaragoza) ; Layunta, E. (Universidad de Zaragoza) ; Mesonero, J.E. (Universidad de Zaragoza) ; Alcalde, A.I.

Resumen: Introduction: Serotonin (5-HT) is a neuromodulator mainly synthesized in the intestinal epithelium. 5-HT regulates the whole intestinal physiology and it has been shown to be essential in intestinal homeostasis. In fact the excess of extracellular 5-HT has been described to contribute to intestinal inflammation. 5-HT availability is in part mediated by the serotonin transporter (SERT), which is responsible for the 5-HT reuptake inside the enterocytes. Recent results have demonstrated that bacteria resident in the intestinal lumen may affect intestinal pathophysiology by acting on the serotoninergic system. This effect is in part carried out through the activation of Toll-like receptors (TLRs) which regulates SERT in the intestinal epithelium. Listeria monocytogenes is a Gram-positive bacteria that causes in humans a serious infection (listeriosis) mainly through the consumption of ready-to-eat foods. Following ingestion, L. monocytogenes has been described to cross the intestinal epithelium and to invade intestinal epithelial cells. However, the effect of L. monocytogenes on intestinal epithelium activity remains unknown...

Idioma: Inglés

Año: 2015

Publicado en: United European Gastroenterology Journal 3, Suppl.1 (2015), P0564 [A311]
ISSN: 2050-6406

Factor impacto JCR: 2.933 (2015)

Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 32 / 79 = 0.405 (2015) - Q2 - T2

Factor impacto SCIMAGO: 1.049 - Oncology (Q2) - Gastroenterology (Q2)

Tipo y forma: Article (Published version)

Área (Departamento): Área Fisiología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Área Tecnología de Alimentos (Dpto. Produc.Animal Cienc.Ali.)