Gestational Age-Specific Reference Ranges for the sFlt-1/PlGF Immunoassay Ratio in Twin Pregnancies
De La Calle, M. ; Delgado, J.L. ; Verlohren, S. ; Escudero, A.I. ; Bartha, J.L. ; Campillos, J.M. (Universidad de Zaragoza) ; Aguarón De La Cruz, A. ; Chantraine, F. ; García Hernández, J.Á. ; Herraiz, I. ; Llurba, E. ; Kurka, H. ; Guo, G. ; Sillman, J. ; Hund, M. ; Perales Marín, A.
Resumen: Objective: Establish reference ranges for the Elecsys® soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) immunoassay ratio in twin pregnancies. Methods: Data analyzed were from 3 prospective studies: Prediction of Short-Term Outcome in Pregnant Women with Suspected Preeclampsia (PE) (PROGNOSIS), Study of Early-onset PE in Spain (STEPS), and a multicenter case-control study. Median, 5th, and 95th percentiles for sFlt-1, PlGF, and the sFlt-1/PlGF ratios were determined for normal twin pregnancies for 7 gestational windows and compared with the previous data for singleton pregnancies. Results: The reference range analysis included 269 women with normal twin pregnancies. Before 29 weeks'' gestation, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios did not differ between twin and singleton pregnancies. From 29 weeks'' gestation to delivery, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios were substantially higher in twin versus singleton pregnancies. sFlt-1 values were higher in women with twin pregnancies across all gestational windows. PlGF values were similar or higher in twin versus singleton pregnancies; PlGF concentrations increased from 10 weeks + 0 days to 28 weeks + 6 days'' gestation. Conclusions: Reference ranges for the sFlt-1/PlGF ratio are similar in women with twin and singleton pregnancies until 29 weeks'' gestation but appear higher in twin pregnancies thereafter.
Idioma: Inglés
DOI: 10.1159/000514378
Año: 2021
Publicado en: Fetal Diagnosis and Therapy 48, 4 (2021), 288–296
ISSN: 1015-3837
Factor impacto JCR: 2.208 (2021)
Categ. JCR: OBSTETRICS & GYNECOLOGY rank: 66 / 85 = 0.776 (2021) - Q4 - T3
Factor impacto CITESCORE: 4.2 - Medicine (Q2)
Factor impacto SCIMAGO: 0.935 - Embryology (Q1) - Radiology, Nuclear Medicine and Imaging (Q1) - Pediatrics, Perinatology and Child Health (Q1) - Medicine (miscellaneous) (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2025-03-07-09:31:50)
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Idioma: Inglés
DOI: 10.1159/000514378
Año: 2021
Publicado en: Fetal Diagnosis and Therapy 48, 4 (2021), 288–296
ISSN: 1015-3837
Factor impacto JCR: 2.208 (2021)
Categ. JCR: OBSTETRICS & GYNECOLOGY rank: 66 / 85 = 0.776 (2021) - Q4 - T3
Factor impacto CITESCORE: 4.2 - Medicine (Q2)
Factor impacto SCIMAGO: 0.935 - Embryology (Q1) - Radiology, Nuclear Medicine and Imaging (Q1) - Pediatrics, Perinatology and Child Health (Q1) - Medicine (miscellaneous) (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2025-03-07-09:31:50)
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Record created 2025-03-07, last modified 2025-03-07