Gestational Age-Specific Reference Ranges for the sFlt-1/PlGF Immunoassay Ratio in Twin Pregnancies

De La Calle, M. ; Delgado, J.L. ; Verlohren, S. ; Escudero, A.I. ; Bartha, J.L. ; Campillos, J.M. (Universidad de Zaragoza) ; Aguarón De La Cruz, A. ; Chantraine, F. ; García Hernández, J.Á. ; Herraiz, I. ; Llurba, E. ; Kurka, H. ; Guo, G. ; Sillman, J. ; Hund, M. ; Perales Marín, A.

Resumen: Objective: Establish reference ranges for the Elecsys® soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) immunoassay ratio in twin pregnancies. Methods: Data analyzed were from 3 prospective studies: Prediction of Short-Term Outcome in Pregnant Women with Suspected Preeclampsia (PE) (PROGNOSIS), Study of Early-onset PE in Spain (STEPS), and a multicenter case-control study. Median, 5th, and 95th percentiles for sFlt-1, PlGF, and the sFlt-1/PlGF ratios were determined for normal twin pregnancies for 7 gestational windows and compared with the previous data for singleton pregnancies. Results: The reference range analysis included 269 women with normal twin pregnancies. Before 29 weeks'' gestation, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios did not differ between twin and singleton pregnancies. From 29 weeks'' gestation to delivery, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios were substantially higher in twin versus singleton pregnancies. sFlt-1 values were higher in women with twin pregnancies across all gestational windows. PlGF values were similar or higher in twin versus singleton pregnancies; PlGF concentrations increased from 10 weeks + 0 days to 28 weeks + 6 days'' gestation. Conclusions: Reference ranges for the sFlt-1/PlGF ratio are similar in women with twin and singleton pregnancies until 29 weeks'' gestation but appear higher in twin pregnancies thereafter.

Idioma: Inglés

DOI: 10.1159/000514378

Año: 2021

Publicado en: Fetal Diagnosis and Therapy 48, 4 (2021), 288–296
ISSN: 1015-3837

Factor impacto JCR: 2.208 (2021)

Categ. JCR: OBSTETRICS & GYNECOLOGY rank: 66 / 85 = 0.776 (2021) - Q4 - T3

Factor impacto CITESCORE: 4.2 - Medicine (Q2)

Factor impacto SCIMAGO: 0.935 - Embryology (Q1) - Radiology, Nuclear Medicine and Imaging (Q1) - Pediatrics, Perinatology and Child Health (Q1) - Medicine (miscellaneous) (Q1)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía)