Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity

Bieganski P. ; Szczupak L. ; Arruebo M. (Universidad de Zaragoza) ; Kowalski K.

Resumen: Rising bacterial antibiotic resistance is a global threat. To deal with it, new antibacterial agents and antiseptic materials need to be developed. One alternative in this quest is the organometallic derivatization of well-established antibacterial drugs and also the fabrication of advanced metal-based materials having antibacterial properties. Metal-based agents and materials often show new modes of antimicrobial action which enable them to overcome drug resistance in pathogenic bacterial strains. This review summarizes recent (2017-2020) progress in the field of organometallic-derived antibacterial drugs and metal-based materials having antibacterial activity. Specifically, it covers organometallic derivatives of antibacterial drugs including ß-lactams, ciprofloxacin, isoniazid, trimethoprim, sulfadoxine, sulfamethoxazole, and ethambutol as well as non-antibacterial drugs like metformin, phenformin and aspirin. Recent advances and reported clinical trials in the use of metal-based nanomaterials as antibiofouling coatings on medical devices, as photocatalytic agents in indoor air pollutant control, and also as photodynamic/photothermal antimicrobial agents are also summarized.

Idioma: Inglés

DOI: 10.1039/d0cb00218f

Año: 2021

Publicado en: RSC chemical biology 2, 2 (2021), 368-386
ISSN: 2633-0679

Factor impacto CITESCORE: 1.7 - Biochemistry, Genetics and Molecular Biology (Q4)

Factor impacto SCIMAGO: 0.847 - Biochemistry (Q1) - Molecular Biology (Q1) - Chemistry (miscellaneous) (Q1)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)