Light activated pulsatile drug delivery for prolonged peripheral nerve block

Prieto, Martin ; Usón, Laura ; García-Salinas, Sara ; Yus, Cristina (Universidad de Zaragoza) ; Landa, Guillermo (Universidad de Zaragoza) ; Alejo, Teresa (Universidad de Zaragoza) ; Lujan, Lluis (Universidad de Zaragoza) ; Pérez, Marta (Universidad de Zaragoza) ; Irusta, Silvia (Universidad de Zaragoza) ; Sebastian, Victor (Universidad de Zaragoza) ; Mendoza, Gracia ; Arruebo, Manuel (Universidad de Zaragoza)

Resumen: Regional anesthesia is widely used in peripheral nerve block and in neuraxial anesthesia to reduce anesthetics systemic side effects and shorten recovery times. However, when applied as a single injection (e.g., peripheral nerve block) it is limited by the duration of its effect. Herein, we develop a thermoresponsive nanogel based on poly(oligoethylene glycol methacrylate) containing the long-lasting anesthetic bupivacaine, which can be externally activated by using near-infrared light due to the photothermal properties of hollow gold nanoparticles embedded in the nanogel which facilitate its phase transition, triggering drug release at a controlled temperature above body temperature. Bupivacaine in vitro release can be repeatedly triggered to achieve a controlled pulsatile release of the drug due to the reversible nature of the thermosensitive nanogel, achieving a spatio-temporal control of the release. In vivo sciatic nerve block demonstrates that whereas the administered dose of free bupivacaine produces sensory block and impaired motor function for 2 h, the equivalent bupivacaine dose included in the developed release system can significantly prolong its neurobehavioral anesthetic effect for over 6 h. This release system can also be reactivated multiple times by subsequent irradiation cycles without observing detrimental toxicity in the infiltrated tissues. © 2022 Elsevier Ltd

Idioma: Inglés

DOI: 10.1016/j.biomaterials.2022.121453

Año: 2022

Publicado en: Biomaterials 283 (2022), 121453 [16 pp.]
ISSN: 0142-9612

Factor impacto JCR: 14.0 (2022)

Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 2 / 45 = 0.044 (2022) - Q1 - T1
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 4 / 96 = 0.042 (2022) - Q1 - T1

Factor impacto CITESCORE: 23.4 - Engineering (Q1) - Chemical Engineering (Q1) - Biochemistry, Genetics and Molecular Biology (Q1) - Materials Science (Q1)

Factor impacto SCIMAGO: 2.716 - Bioengineering (Q1) - Biomaterials (Q1) - Nanoscience and Nanotechnology (Q1) - Ceramics and Composites (Q1) - Mechanics of Materials (Q1) - Biophysics (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/ERC-2013-CoG-614715
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/MS19-00092
Financiación: info:eu-repo/grantAgreement/ES/MCINN/PRE2018-085769
Financiación: info:eu-repo/grantAgreement/ES/MICINN BES-2015-073735

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Tecnologi. Medio Ambiente (Dpto. Ing.Quím.Tecnol.Med.Amb.)