Synthesis, characterizacion and study of novel heterobimetallic RAPTA-type Ru(II) complexes
Kordestani, Nazanin ; Martinez-Aguilera, Alvaro ; Abas, Elisa ; Grasa, Laura (Universidad de Zaragoza) ; Scalambra, Franco ; Romerosa, Antonio
Resumen: The new monometallic RAPTA complex [RuCl2(η6-p-cym)(dmPTA-κP)](CF3SO3)2 (1) and novel heterobimetallic complexes [RuCl2(η6-p-cym)-μ-(dmoPTA)-(1κP:2κ2N,N′-M(L)Cl2)] (M = Cu (3); M = Cu, L = DMF (3·3DMF); M = Pd (4)) have been synthesized and characterized (dmPTA = N,N′-dimethyl-1,3,5-triaza-7-phosphaadamantane; dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane). The synthesized complexes have been fully characterized by elemental analysis and spectroscopic techniques. The crystal structure of the complexes 2, 3·3DMF and 4 were determined by single-crystal X-ray diffraction. The stability of complexes was studied in water and DMSO at room temperature and 37 °C. The anticancer activity against intestinal Caco-2/TC7 cells was studied.
Idioma: Inglés
DOI: 10.1016/j.ica.2025.122948
Año: 2025
Publicado en: INORGANICA CHIMICA ACTA 589 (2025), 122948 [9 pp.]
ISSN: 0020-1693
Tipo y forma: Article (Published version)
Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2025-10-30-14:39:50)
Visitas y descargas
Idioma: Inglés
DOI: 10.1016/j.ica.2025.122948
Año: 2025
Publicado en: INORGANICA CHIMICA ACTA 589 (2025), 122948 [9 pp.]
ISSN: 0020-1693
Tipo y forma: Article (Published version)
Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2025-10-30-14:39:50)
Permalink:
Visitas y descargas
Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Fisiología
Record created 2025-10-30, last modified 2025-10-30