Synthesis, characterizacion and study of novel heterobimetallic RAPTA-type Ru(II) complexes

Kordestani, Nazanin ; Martinez-Aguilera, Alvaro ; Abas, Elisa ; Grasa, Laura (Universidad de Zaragoza) ; Scalambra, Franco ; Romerosa, Antonio

Resumen: The new monometallic RAPTA complex [RuCl2(η6-p-cym)(dmPTA-κP)](CF3SO3)2 (1) and novel heterobimetallic complexes [RuCl2(η6-p-cym)-μ-(dmoPTA)-(1κP:2κ2N,N′-M(L)Cl2)] (M = Cu (3); M = Cu, L = DMF (3·3DMF); M = Pd (4)) have been synthesized and characterized (dmPTA = N,N′-dimethyl-1,3,5-triaza-7-phosphaadamantane; dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane). The synthesized complexes have been fully characterized by elemental analysis and spectroscopic techniques. The crystal structure of the complexes 2, 3·3DMF and 4 were determined by single-crystal X-ray diffraction. The stability of complexes was studied in water and DMSO at room temperature and 37 °C. The anticancer activity against intestinal Caco-2/TC7 cells was studied.

Idioma: Inglés

DOI: 10.1016/j.ica.2025.122948

Año: 2025

Publicado en: INORGANICA CHIMICA ACTA 589 (2025), 122948 [9 pp.]
ISSN: 0020-1693

Tipo y forma: Article (Published version)

Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)