Associations between dietary amino acid intakes and blood concentration levels
Iguacel, I. (Universidad de Zaragoza) ; Schmidt, J.A. ; Perez-Cornago, A. ; Van Puyvelde, H. ; Travis, R. ; Stepien, M. ; Scalbert, A. ; Casagrande, C. ; Weiderpass, E. ; Riboli, E. ; Schulze, M.B. ; Skeie, G. ; Bodén, S. ; Boeing, H. ; Cross, A.J. ; Harlid, S. ; Jensen, T.E. ; Huerta, J.M. ; Katzke, V. ; Kühn, T. ; Lujan-Barroso, L. ; Masala, G. ; Rodriguez-Barranco, M. ; Rostgaard-Hansen, A.L. ; Van der Schouw, Y.T. ; Vermeulen, R. ; Tagliabue, G. ; Tjønneland, A. ; Trevisan, M. ; Ferrari, P. ; Gunter, M.J. ; Huybrechts, I.
Resumen: Background and aims: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Methods: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations.
Results: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (-0.15 = r = 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results.
Conclusions: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.
Idioma: Inglés
DOI: 10.1016/j.clnu.2021.04.036
Año: 2021
Publicado en: Clinical Nutrition 40, 6 (2021), 3772-3779
ISSN: 0261-5614
Factor impacto JCR: 7.643 (2021)
Categ. JCR: NUTRITION & DIETETICS rank: 13 / 90 = 0.144 (2021) - Q1 - T1
Factor impacto CITESCORE: 9.9 - Nursing (Q1) - Medicine (Q1)
Factor impacto SCIMAGO: 1.553 - Nutrition and Dietetics (Q1) - Critical Care and Intensive Care Medicine (Q1)
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2026-01-19-14:38:46)
Visitas y descargas
Methods: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations.
Results: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (-0.15 = r = 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results.
Conclusions: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.
Idioma: Inglés
DOI: 10.1016/j.clnu.2021.04.036
Año: 2021
Publicado en: Clinical Nutrition 40, 6 (2021), 3772-3779
ISSN: 0261-5614
Factor impacto JCR: 7.643 (2021)
Categ. JCR: NUTRITION & DIETETICS rank: 13 / 90 = 0.144 (2021) - Q1 - T1
Factor impacto CITESCORE: 9.9 - Nursing (Q1) - Medicine (Q1)
Factor impacto SCIMAGO: 1.553 - Nutrition and Dietetics (Q1) - Critical Care and Intensive Care Medicine (Q1)
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2026-01-19-14:38:46)
Permalink:
Visitas y descargas
Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Enfermería
Record created 2026-01-19, last modified 2026-01-19