Are circulating cytokines reliable biomarkers for amyotrophic lateral sclerosis?

Moreno Martínez, Laura (Universidad de Zaragoza) ; Calvo, Ana Cristina (Universidad de Zaragoza) ; Muñoz, María Jesús (Universidad de Zaragoza) ; Osta, Rosario (Universidad de Zaragoza)

Resumen: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that has no effective treatment. The lack of any specific biomarker that can help in the diagnosis or prognosis of ALS has made the identification of biomarkers an urgent challenge. Multiple panels have shown alterations in levels of numerous cytokines in ALS, supporting the contribution of neuroinflammation to the progressive motor neuron loss. However, none of them is fully sensitive and specific enough to become a universal biomarker for ALS. This review gathers the numerous circulating cytokines that have been found dysregulated in both ALS animal models and patients. Particularly, it highlights the opposing results found in the literature to date, and points out another potential application of inflammatory cytokines as therapeutic targets.

Idioma: Inglés

DOI: 10.3390/ijms20112759

Año: 2019

Publicado en: International Journal of Molecular Sciences 20, 11 (2019), [17 pp.]
ISSN: 1661-6596

Factor impacto JCR: 4.556 (2019)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 48 / 177 = 0.271 (2019) - Q2 - T1
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 74 / 297 = 0.249 (2019) - Q1 - T1

Factor impacto SCIMAGO: 1.317 - Medicine (miscellaneous) (Q1) - Physical and Theoretical Chemistry (Q1) - Computer Science Applications (Q1) - Inorganic Chemistry (Q1) - Spectroscopy (Q1) - Organic Chemistry (Q1) - Molecular Biology (Q2) - Catalysis (Q2)

Financiación: info:eu-repo/grantAgreement/ES/FIS-FEDER/PI17-00949

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Farmacología (Dpto. Farmacología y Fisiolog.)