Failure damage mechanical properties of thoracic and abdominal porcine aorta layers and related constitutive modeling: phenomenological and microstructural approach

Peña Baquedano, Juan Antonio (Universidad de Zaragoza) ; Martínez, Miguel A. (Universidad de Zaragoza) ; Peña, Estefanía (Universidad de Zaragoza)

Resumen: Despite increasing experimental and analytical efforts to investigate the irreversible effects of arterial tissue failure, the underlying mechanisms are still poorly understood. The goal of this study was to characterize the failure properties of the intact wall and each separated layer (intima, media, and adventitia) of the descending thoracic and infrarenal abdominal aorta and to test the hypothesis that the failure properties of layer-separated tissue depend on the location of the aorta. To test this hypothesis, we performed uniaxial tests to study the mechanical behavior of both intact and layer-separated porcine aortic tissue samples taken from descending thoracic and infrarenal abdominal aorta until complete failure. The fracture stress is higher in the infrarenal abdominal aorta than in the equivalent descending thoracic aorta. It was also found that the extrapolation of the elastic mechanical properties from the physiological to the supra-physiological regime for characterizing the mechanical response of the aorta would be inappropriate. Finally, we report values of constitutive parameters using phenomenological and microstructural damage models based on continuum damage mechanics theory. The phenomenological damage model gives an excellent fit to the experimental data compared to the microstructural damage model. Although the fitting results of the phenomenological model are better, the microstructural models can include physically motivated aspects obtained from experiments.

Idioma: Inglés

DOI: 10.1007/s10237-019-01170-0

Año: 2019

Publicado en: BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 18, 6 (2019), 1709-1730
ISSN: 1617-7959

Factor impacto JCR: 2.527 (2019)

Categ. JCR: ENGINEERING, BIOMEDICAL rank: 42 / 87 = 0.483 (2019) - Q2 - T2
Categ. JCR: BIOPHYSICS rank: 34 / 71 = 0.479 (2019) - Q2 - T2

Factor impacto SCIMAGO: 0.85 - Mechanical Engineering (Q1) - Modeling and Simulation (Q1) - Biotechnology (Q2)

Financiación: info:eu-repo/grantAgreement/ES/CSIC-IMB-CNM/ICTS NANBIOSIS-SU8 Unit-CIBER-BBN
Financiación: info:eu-repo/grantAgreement/ES/DGA/T24-17R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2016-76630-C2-1-R

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Expresión Gráfica en Ing. (Dpto. Ingeniería Diseño Fabri.)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)