Magnetic hyperthermia with e-Fe2O3 nanoparticles

Gu, Y. ; Yoshikiyo, M. ; Namai, A. ; Bonvin, D. ; Martinez, A. (Universidad de Zaragoza) ; Piñol, R. (Universidad de Zaragoza) ; Téllez, P. (Universidad de Zaragoza) ; Silva, N.J.O. ; Ahrentorp, F. ; Johansson, C. ; Marco-Brualla, J. ; Moreno-Loshuertos, R. (Universidad de Zaragoza) ; Fernández-Silva, P. (Universidad de Zaragoza) ; Cui, Y. ; Ohkoshi, S.I. ; Millán, A. (Universidad de Zaragoza)

Resumen: Biocompatibility restrictions have limited the use of magnetic nanoparticles for magnetic hyperthermia therapy to iron oxides, namely magnetite (Fe3O4) and maghemite (ε-Fe2O3). However, there is yet another magnetic iron oxide phase that has not been considered so far, in spite of its unique magnetic properties: ε-Fe2O3. Indeed, whereas Fe3O4 and ε-Fe2O3 have a relatively low magnetic coercivity, ε-Fe2O3 exhibits a giant coercivity. In this report, the heating power of ε-Fe2O3 nanoparticles in comparison with ε-Fe2O3 nanoparticles of similar size (~20 nm) was measured in a wide range of field frequencies and amplitudes, in uncoated and polymer-coated samples. It was found that ε-Fe2O3 nanoparticles primarily heat in the low-frequency regime (20-100 kHz) in media whose viscosity is similar to that of cell cytoplasm. In contrast, ε-Fe2O3 nanoparticles heat more effectively in the high frequency range (400-900 kHz). Cell culture experiments exhibited no toxicity in a wide range of nanoparticle concentrations and a high internalization rate. In conclusion, the performance of ε-Fe2O3 nanoparticles is slightly inferior to that of ¿-Fe2O3 nanoparticles in human magnetic hyperthermia applications. However, these ε-Fe2O3 nanoparticles open the way for switchable magnetic heating owing to their distinct response to frequency.

Idioma: Inglés

DOI: 10.1039/d0ra04361c

Año: 2020

Publicado en: RSC Advances 10, 48 (2020), 28786-28797
ISSN: 2046-2069

Factor impacto JCR: 3.361 (2020)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 81 / 178 = 0.455 (2020) - Q2 - T2

Factor impacto SCIMAGO: 0.746 - Chemistry (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E11-17R
Financiación: info:eu-repo/grantAgreement/EC/H2020/801305/EU/Nanoparticles-based 2D thermal bioimaging technologies/NanoTBTech
Financiación: info:eu-repo/grantAgreement/EC/H2020/829162/EU/Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation/HOTZYMES
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/PGC2018-095795-B-I00

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Tecnología Electrónica (Dpto. Ingeniería Electrón.Com.)
Área (Departamento): División: Serv. Transversales (Serv.Gral. Apoyo Investigación)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
Área (Departamento): Área Física Materia Condensada (Dpto. Física Materia Condensa.)