Unravelling cell migration: defining movement from the cell surface

Merino Casallo, Francisco (Universidad de Zaragoza) ; Gomez Benito, Maria Jose (Universidad de Zaragoza) ; Hervas Raluy, Silvia (Universidad de Zaragoza) ; Garcia-Aznar, Jose Manuel (Universidad de Zaragoza)

Resumen: Cell motility is essential for life and development. Unfortunately, cell migration is also linked to several pathological processes, such as cancer metastasis. Cells’ ability to migrate relies on many actors. Cells change their migratory strategy based on their phenotype and the properties of the surrounding microenvironment. Cell migration is, therefore, an extremely complex phenomenon. Researchers have investigated cell motility for more than a century. Recent discoveries have uncovered some of the mysteries associated with the mechanisms involved in cell migration, such as intracellular signaling and cell mechanics. These findings involve different players, including transmembrane receptors, adhesive complexes, cytoskeletal components , the nucleus, and the extracellular matrix. This review aims to give a global overview of our current understanding of cell migration.

Idioma: Inglés

DOI: 10.1080/19336918.2022.2055520

Año: 2022

Publicado en: Cell adhesion & migration 16, 1 (2022), 25-64
ISSN: 1933-6918

Factor impacto JCR: 3.2 (2022)

Categ. JCR: CELL BIOLOGY rank: 127 / 191 = 0.665 (2022) - Q3 - T3

Factor impacto CITESCORE: 6.7 - Neuroscience (Q2) - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 0.746 - Cellular and Molecular Neuroscience (Q3) - Cell Biology (Q3)

Financiación: info:eu-repo/grantAgreement/EC/H2020/826494/EU/PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers/PRIMAGE
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C21
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BES-2016-076291

Tipo y forma: Article (Published version)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)